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Acknowledgements This study was funded by Hualien Tzu Chi Hospital with Grant Number TCRD 108-36
Interestingly, when FOXO4 expression was silenced in TM3 cells using siRNA prior to H2O2 treatment, cell viability decreased, and apoptosis increased, despite elevated p53 levels
Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Olliaro and Mussano, 2003
doi:10.1177/0194599813497921
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